摘要：

Highly selective asymmetric induction can be achieved in the reduction of acyclic β-hydroxyketones via boron chelates. Treatment of β-hydroxyketones ( 1) with tributyl or tri-isobutylborane and successively with sodium borohydride afforded syn-1,3-diols ( 3) in highly stereo-selective manner, Syn -α-substituted-β -hydroxyketones ( 8) were also reduced to give syn, syn-1,3-diols ( 9) exclusively. The reaction was further applied to the convenient preparation of 3-deoxy-hexoses.

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