The paradox of autophagy and its implication in cancer etiology and therapy

Autophagy is a cellular self-catabolic process in which cytoplasmic constituents are sequestered in double membrane vesicles that fuse with lysosomes where...

A Eisenberg-Lerner，A Kimchi - 《Apoptosis》

Markers for Microscopic Imaging of Lymphangiogenesis and Angiogenesis

Imaging of lymphangiogenesis and angiogenesis requires robust and unambiguous markers of lymphatic and blood vessels. Although much progress has been made ...

P Baluk，DM Mcdonald - 《Annals of the New York Academy of Sciences》

A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - dacarbazine in patients with stage IV metastatic...

BACKGROUND:The alpha v beta 3 (v尾3) integrin is involved in intracellular signaling regulating cell proliferation, migration, and differentiation and is i...

 - 《Cancer》

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis

The ras/Raf/Mek/Erk pathway plays a central role in coordinating endothelial cell activities during angiogenesis. Transcription factors Ets1 and Ets2 are t...

G Wei，R Srinivasan，CZ Cantemirstone，... - 《Blood》

The Tumor Microenvironment Contribution to Development, Growth, Invasion and Metastasis of Head and Neck Squamous Cell Carcinomas

Head and neck squamous cell carcinoma (HNSCC) is a complex tissue that contains tumor cells and the surrounding stroma, which is populated by different typ...

K Sittichai - 《Journal of Cancer》

A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents

The discovery of molecules with anti-angiogenic properties has led to promising new strategies for the treatment of diseases characterized by excessive new...

Peace，MabetaMichael，S.，... - 《Angiogenesis》

Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic c...

Detection of pancreatic cancer remains a high priority and effective diagnostic tools are needed for clinical applications. Many cancer cells overexpress i...

RH Kimura，R Teed，BJ Hackel，... - 《Clinical Cancer Research An Official Journal of the American Association for Cancer Research》

Angioprevention with fenretinide: Targeting angiogenesis in prevention and therapeutic strategies

Clinical trials have revealed that N-(4-hydroxyphenyl) retinamide (4HPR; fenretinide), a synthetic retinoic acid derivative, is a highly active and promisi...

I Sogno，R Venè，N Ferrari，... - 《Critical Reviews in Oncology/hematology》

Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE-MRI in a longitudinal in vivo...

The aim of this study was to investigate the effect of inhibiting αvβ3/αvβ5 integrins by cilengitide in experimentally induced breast cancer bone metas...

Tobias Buerle，D Komljenovic，M Merz，... - 《International Journal of Cancer》

Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming H...

We previously reported that indole-3-carbinol (I3C), found in cruciferous vegetables, suppresses angiogenesis in vivo and in vitro. However, the underlying...

K Kunimasa，T Kobayashi，K Kaji，... - 《Journal of Nutrition》