摘要：

Presents research which described a new gene, Slimb, which negatively regulates signal transduction pathways. Roles of members of the Hedgehog (Hh) and Wnt/Wingless (Wg) families of secreted proteins; Hh and Wg signal transduction; Effects of loss of Slimb function; Slimb gene encoding; Targets of Slimb protein; Hh and Wg in gene expression; Slimb-mediated proteolysis.

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