Stereochemical control in diastereoselective reduction of α-substituted-β-ketoesters using a reductase purified from Kluyveromyces marxianus
摘要：
An NADPH-dependent carbonyl reductase that shows (3 R )-selective reducing activity for α-substituted-β-ketoesters was purified from Kluyveromyces marxianus and racemic alkyl 2-substituted-3-oxobutanoates were reduced to the corresponding (2 S ,3 R )- or (2 R ,3 R )-2-substituted-3-hydroxybutanoates with enantiomeric purity (> 99%) and diastereoselectivity (24 98%).
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关键词：
asymmetric reduction biocatalyst carbonyl reductase diastereoselectivity Kluyveromyces marxianus
DOI：
10.1023/A:1020649316546
被引量：
年份：
2002
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