摘要：

Disclosed is a pharmaceutical composition including a therapeutic quantity of an a joint restorative compound selected from aminosugars, chondroitin, collagen 2, or methyl sulfonyl methane; and a therapeutic quantity of a COX-2 inhibitor having an IC50-WHMA COX-2/COX-1 ratio ranging from about 0.23 to about 3.33. Also disclosed are methods for the treatment, regeneration, and repair of connective tissue in mammals and methods for treating osteoarthritis, rheumatoid arthritis or acute pain utilizing the disclosed

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