Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes
摘要：
Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes with formaldehyde has been developed, which furnished the corresponding α-hydroxymethylated adducts with high chemo- and enantioselectivity. The reaction is catalyzed by proline derivatives and is a simple method for the enantioselective synthesis of α-hydroxymethylated ketones and aldehydes, and C-2 symmetric diols.
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DOI：
10.1016/j.tetlet.2004.06.062
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年份：
2004
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来源期刊
Cheminform
2004
引用走势
2007
被引量：46
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