摘要：

The Ouchterlony technique of double immunodiffusion, combined with some physicochemical characterization of the antigens involved, has been used to characterize several antigen-antibody systems of importance in certain connective tissue diseases, notably systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjögren's syndrome, rheumatoid arthritis, scleroderma, and poly- and dermatomyositis (1–12). These systems appear to have not only considerable diagnostic significance but also importance in determining prognosis and disease course.

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