Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
摘要：
The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
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关键词：
Humans Epithelium Disease Progression Transcription Factors Repressor Proteins Homeodomain Proteins Cadherins Signal Transduction Helix-Turn-Helix Motifs Phenotype
DOI：
10.1038/nrc2131
被引量：
年份：
2007
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