摘要：

Non-covalent complementation of peptide hormonal fragments produces a recombinant with the hormonal activity of the native hormone. The fragments employed can be natural, synthetic or mixed natural-synthetic origin and can contain less than the total amino acid sequence of the native hormone or fragments derived from related hormones. In a preferred embodiment the human growth hormone (HGH) fragments [Cys(Cam) 53 -HGH-(1-134)] and [Cys(Cam) 165 ,182,189 -HGH-(141-191)] undergo non-covalent complementation to yield a recombinant having full growth-promoting and prolactin potency of the native human growth hormone.

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