Palladium Catalyzed Synthesis of Some Novel (Spirocycloalkenyl) Trimethylsilylacetylenes
摘要:
A highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions.
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DOI:
10.1002/chin.200845124
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年份:
2013
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2013
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