摘要：

N,N'-substituted 3,7-diazabicyclo[3.3.1]nonanes of general formula 1 wherein meanings of radicals correspond to the meanings indicated in the specification, having the property of the both positive allosteric modulators of the AMPA receptors, and potential AMPA receptor blockers, are used for the treatment and prevention of neurodegenerative diseases, and may be particularly used for the treatment of AD (Alzheimer's disease), PD (Parkinson's disease), and other neurodegenerative pathologies. The instant invention also relates to pharmaceutical compositions of compounds 1 and to a method for the treatment of the diseases indicated above.

展开