Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
摘要:
A series of methylated flavonols and two methyl flavones have been identified in the exudate of the American gumweed species Grindelia glutinosa and Grindelia robusta. They resemble the flavonoid patterns observed in other species of this genus, which thus shows a tendency for accumulation of methylated flavonols.
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关键词:
Microsomes, Liver Animals Pharmaceutical Preparations Metabolic Clearance Rate Pharmacokinetics Biotransformation
DOI:
10.1016/0006-2952(94)90520-7
被引量:
年份:
1994
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