A new 1,1'-binaphthyl-based catalyst for the enantioselective phenylacetylene addition to aromatic aldehydes without using a titanium complex.
摘要：
[reaction: see text] A novel 1,1'-binaphthyl compound containing bulky 3,3'-aryl substituents is found to catalyze the reaction of a terminal alkyne with various aromatic aldehydes under mild conditions to generate chiral propargyl alcohols with 80-94% ee. Unlike the previously reported 1,1'-binaphthyl catalysts, this new compound does not require the use of a titanium complex and the pre-preparation of an alkynylzinc. This has greatly simplified the experimental procedure for this reaction.
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关键词：
polyphenylalkyne derivatives (tolan derivatives addition reactions diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism catalysis, phase‐transfer catalysis
DOI：
10.1021/ol027110q
被引量：
年份：
2002
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