Comparison of anaesthetic and cardiorespiratory effects of xylazine or medetomidine in combination with tiletamine/zolazepam in pigs

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摘要：

Two different combinations of were evaluated and compared in a prospective randomised crossover experimental study in . One of the two combinations was administered intramuscularly to each of six Landrace x Yorkshire mixed-breed . The combinations were: 2.2 mg/kg xylazine and 4.4 mg/kg tiletamine/zolazepam (2.2 mg/kg tiletamine plus 2.2 mg/kg zolazepam) (XTZ); and 0.04 mg/kg and 4.4 mg/kg tiletamine/zolazepam (MTZ). The anaesthesia and recovery times, score for effect and cardiopulmonary parameters were recorded for each . Anaesthesia was successfully induced in all of the . Both drug combinations provided smooth induction and good immobilisation, and their effects were similar. In both treatment groups, the mean heart rate decreased significantly five minutes after the drugs were administered and remained consistent for 70 minutes, with no significant difference between the XTZ and MTZ groups. However, there were differences in cardiopulmonary effects between the groups. The arterial pressure was significantly higher in the MTZ group than in the XTZ group. The initial associated with was more marked than the initial associated with xylazine. Arterial oxygen partial pressure and arterial oxygen saturation decreased significantly from baseline in both groups. The respiratory rates and levels of blood gases were similar in both groups. Hypoventilation and hypoxaemia were observed in both groups. The scores for effect, induction time, anaesthesia time and recovery times were similar in the two groups.

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关键词：

Animals Zolazepam Anesthetics, Combined Blood Gas Analysis Prospective Studies Cross-Over Studies Blood Pressure Heart Rate Xylazine Respiratory Rate