摘要：

The response of a transplantable mammary carcinoma in CBA mice to single doses and two or five fractions of X rays, with and without the hypoxic cell sensitizer Ro-07-0582, has been tested using delay of tumor regrowth as the measure of response. In the tumors treated with X rays alone the processes of repair of sublethal injury, and reoxygenation between fractions, appeared to counteract each other so that no extra dose was needed to achieve a particular level of damage when fractionated irradiation was used. When Ro-07-0582 was administered shortly before each radiation dose, however, the tumor cells were made more uniformly radiosensitive, so that without the complication of hypoxia and reoxygenation their repair capacity could be measured. The repair capacity measured in this tumor was approximately 50-70% of that observed in skin. The response of the tumor to different treatments has been expressed in relation to the response of mouse skin, as an example of normal tissue. With X rays alone, more tumo...

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