mitotic kinase, NIMA, encoded by the Aspergillus nimA gene; pure WW domain of a Pin1 polypeptide which interacts with NIMA; a Peptidyl-prolyl cis/trans isomerases (PPIase); drug target; Pin1 is a PPIase known to be essential for life
摘要：
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.
展开
DOI：
US7125955 B2
被引量：
年份：
2006
通过文献互助平台发起求助，成功后即可免费获取论文全文。
请先登入
相似文献
参考文献
引证文献
研究点推荐
辅助模式
0
引用
文献可以批量引用啦~
欢迎点我试用！
