摘要：

In the present study the relationships between the ejection time, heart rate, and stroke volume in normal individuals and in patients with various cardiovascular disorders were investigated. Ejection time was measured from the carotid or subclavian pulse tracing, and stroke volume was derived from direct measurements of blood flow. In normal individuals, ejection time varied inversely with heart rate and directly with stroke volume. In patients with nonvalvular heart disease and cardiac failure, ejection time was usually low relative to heart rate but tended to fall within normal limits relative to stroke volume. At the level of stroke volume observed in the patients with congestive heart failure, the mean rate of left ventricular ejection was within normal limits. Prolongation of ejection time relative to stroke volume was observed in patients with aortic insufficiency and in those with isolated aortic stenosis. The degree of prolongation in ejection time was well correlated with the severity of the aortic valvular disease. In patients with mitral valvular disease, including isolated mitral stenosis, as well as in those with mild to moderate mitral regurgitation, ejection time fell within the normal range relative to stroke volume. In patients with severe hypertensive disease, ejection time fell within the normal or low normal range relative to stroke volume. In 3 patients with pericardial disease an abnormal phasic respiratory variation in ejection time was observed. The present observations on temporal phenomena in cardiac ejection suggests the practical application of these techniques in the evaluation of patients with various cardiovascular disorders.

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