PPARs: therapeutic targets for metabolic disease.
摘要：
The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ, PPAR-α and PPAR-δ, are nuclear receptors that have been the focus of extensive research during the past decade. These receptors function as lipid sensors that coordinately regulate the expression of large gene arrays and, thereby, modulate important metabolic events. They are also the targets of drugs that are effective in the treatment of metabolic disorders (type 2 diabetes mellitus and atherosclerosis) that afflict industrialized societies at epidemic levels. Ongoing research indicates that modulation of PPAR activity might be an effective therapy for additional maladies associated with the metabolic syndrome, including obesity. Novel PPAR ligands are now being developed that possess broader efficacies and improved tolerability compared with currently available therapeutic agents.
展开
DOI：
10.1016/j.tips.2005.03.003
被引量：
年份：
2005
Elsevier
掌桥科研
万方医学
Ingenta
dx.doi.org
查看更多
Cell Press
Cell Press
(全网免费下载)
NCBI
Oxford Univ Press
NCBI
Europe PMC
NRC Research Press
dialnet.unirioja.es
ResearchGate
EBSCO
EBSCO
science-open.com
epires-journal.com
d.scholar.cnki.net
mysciencework.com
cghjournal.org
pharmrev.aspetjournals.org
jlr.org
www.socolar.com
jacionline.org
mendeley.com
emboj.embopress.org
pubfacts.com
deepdyve.com
onAcademic
frontiersin.org
Cell Press
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
