Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
申请(专利)号:
US07/492462
申请日期:
19900307
公开/公告号:
US05143854A
公开/公告日期:
19920901
申请(专利权)人:
AFFYMAX TECHNOLOGIES N.V.
被引量:
摘要:
Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating the steps of activation and attachment until polypeptides of the desired length and sequences are synthesized. The resulting array can be used to determine which peptides on the array can bind to a receptor.
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