Regulation of supply and demand for maternal nutrients in mammals by imprinted genes

The placenta has evolved in eutherian mammals primarily to provide nutrients for the developing fetus. The genetic control of the regulation of supply and ...

W Reik，Miguel Constncia，A Fowden，... - 《Journal of Physiology》

Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver-Russell syndrome.

Silver-Russell syndrome (SRS, OMIM 180860) is a congenital disorder characterized by severe intrauterine and postnatal growth retardation, dysmorphic facia...

C Gicquel，S Rossignol，S Cabrol，... - 《Nature Genetics》

Developmental Origins of Disease Paradigm: A Mechanistic and Evolutionary Perspective

Fetal growth is determined by the interaction between the environment and the fetal genome. The fetal environment, in turn, is determined by the maternal e...

PD Gluckman，MA Hanson - 《Pediatric Research》

Psychoneuroendocrine processes in human pregnancy influence fetal development and health

Individual differences in psychoneuroendocrine function play an important role in health and disease. Developmental models postulate that these individual ...

PD Wadhwa - 《Psychoneuroendocrinology》

Nongenetic Inheritance and Its Evolutionary Implications

Modern evolutionary biology is founded on the Mendelian-genetic model of inheritance, but it is now clear that this model is incomplete. Empirical evidence...

R Bonduriansky，T Day - 《Annual Review of Ecology Evolution & Systematics》

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes

Modern evolutionary biology is founded on the Mendelian-genetic model of inheritance, but it is now clear that this model is incomplete. Empirical evidence...

Reik，W.，Constancia，... - 《Journal of Physiology London Then Cambridge》

Epigenetics and the placenta

BACKGROUND: The placenta is of utmost importance for intrauterine fetal development and growth. Deregulation of placentation can lead to adverse outcomes f...

ECM Nelissen，APAV Montfoort，JCM Dumoulin - 《Human Reproduction Update》

Convergent evolution of genomic imprinting in plants and mammals

Parental genomic imprinting is characterized by the expression of a selected panel of genes from one of the two parental alleles. Recent evidence shows tha...

R Feil，F Berger - 《Trends in Genetics》

The Importance of Imprinting in the Human Placenta

As a field of study, genomic imprinting has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and ...

JM Frost，GE Moore，AC Ferguson-Smith - 《Plos Genetics》

Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring

p pBackground/p pmiRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-t...

J Zhang，F Zhang，X Didelot，... - 《Bmc Genomics》