Nature-Inspired Total Synthesis of ()-Fusarisetin A
摘要：
A concise, protecting group-free total synthesis of (-)-fusarisetin A (1) was efficiently achieved in nine steps from commercially available (S)-(-)-citronellal. The synthetic approach was inspired by our proposed biosynthesis of 1. Key transformations of our strategy include a facile construction of the decalin moiety that is produced via a stereoselective IMDA reaction and a one-pot TEMPO-induced radical cyclization/aminolysis that forms the C ring of 1. Our route is amenable to analogue synthesis for biological evaluation.
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关键词：
Heterocyclic Compounds with 4 or More Rings Antineoplastic Agents Molecular Conformation Stereoisomerism
DOI：
10.1021/ja300807e
被引量：
年份：
2012
国家科技图书文献中心
(权威机构)
ACS
万方医学
掌桥科研
dx.doi.org
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