C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells
阅读量：
178
摘要：
Removal of apoptotic cells is essential for maintenance of tissue homeostasis, organogenesis, remodeling, development, and maintenance of the immune system, protection against neoplasia, and resolution of inflammation. The mechanisms of this removal involve recognition of the apoptotic cell surface and initiation of phagocytic uptake into a variety of cell types. Here we provide evidence that C1q and mannose binding lectin (MBL), a member of the collectin family of proteins, bind to apoptotic cells and stimulate ingestion of these by ligation on the phagocyte surface of the multifunctional protein, calreticulin (also known as the cC1qR), which in turn is bound to the endocytic receptor protein CD91, also known as the α-2-macroglobulin receptor. Use of these proteins provides another example of apoptotic cell clearance mediated by pattern recognition molecules of the innate immune system. Ingestion of the apoptotic cells through calreticulin/CD91 stimulation is further shown to involve the process of macropinocytosis, implicated as a primitive and relatively nonselective uptake mechanism for C1q- and MBL-enhanced engulfment of whole, intact apoptotic cells, as well as cell debris and foreign organisms to which these molecules may bind.
展开
DOI：
10.1084/jem.194.6.781
被引量：
年份：
2001
BMJ
掌桥科研
Semantic Scholar
(全网免费下载)
Europe PMC
Europe PMC
(全网免费下载)
查看更多
Oxford Univ Press
NCBI
BioMed Central
Cell Press
NCBI
NCBI
(全网免费下载)
JBC
AACR
ResearchGate
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
Citeseer
ukpmc.ac.uk
(全网免费下载)
circres.ahajournals.org
readcube.com
ukpmc.ac.uk
mendeley.com
jacionline.org
f1000.com
haematologica.org
citeseer.ist.psu.edu
(全网免费下载)
rupress.org
biomedsearch.com
(全网免费下载)
core.ac.uk
deepdyve.com
jem.rupress.org
science-open.com
(全网免费下载)
scienceopen.com
www.socolar.com
Pubmed Central
(全网免费下载)
bloodjournal.org
biochemj.org
jimmunol.org
mcponline.org
celltherapyjournal.org
onacademic.com
jleukbio.org
science-open.com
biolreprod.org
jcs.biologists.org
cghjournal.org
jem.rupress.org
(全网免费下载)
fasebj.org
cvi.asm.org
cshperspectives.cshlp.org
scienceopen.com
(全网免费下载)
ajplung.physiology.org
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
ukpmc.ac.uk
(全网免费下载)
jem.rupress.org
(全网免费下载)
citeseer.ist.psu.edu
(全网免费下载)
biomedsearch.com
(全网免费下载)
scienceopen.com
(全网免费下载)
Pubmed Central
(全网免费下载)
science-open.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
