Antigen-specific memory B cell development

来自 Semantic Scholar

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阅读量：

121

作者：

LJ Mcheyzer-Williams，MG Mcheyzer-Williams

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摘要：

Helper T (Th) cell-regulated B cell immunity progresses in an ordered cascade of cellular development that culminates in the production of antigen-specific memory B cells. The recognition of peptide MHC class II complexes on activated antigen-presenting cells is critical for effective Th cell selection, clonal expansion, and effector Th cell function development (Phase I). Cognate effector Th cell-B cell interactions then promote the development of either short-lived plasma cells (PCs) or germinal centers (GCs) (Phase II). These GCs expand, diversify, and select high-affinity variants of antigen-specific B cells for entry into the long-lived memory B cell compartment (Phase III). Upon antigen rechallenge, memory B cells rapidly expand and differentiate into PCs under the cognate control of memory Th cells (Phase IV). We review the cellular and molecular regulators of this dynamic process with emphasis on the multiple memory B cell fates that develop in vivo.

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关键词：

B-Lymphocytes Immunologic Memory B淋巴细胞免疫记忆

DOI：

10.1146/annurev.immunol.23.021704.115732

被引量：

1187

年份：

2005