p53 and its mutants in tumor cell migration and invasion
阅读量：
119
摘要：
In about half of all human cancers, the tumor suppressor p53 protein is either lost or mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 protein. Loss of p53 function is well known to influence cell cycle checkpoint controls and apoptosis. But it is now clear that p53 regulates other key stages of metastatic progression, such as cell migration and invasion. Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function.
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关键词：
Animals Humans Mutant Proteins Neoplasm Invasiveness Neoplasms Cell Movement Tumor Suppressor Protein p53
DOI：
10.1083/jcb.201009059
被引量：
年份：
2011
Taylor & Francis
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