A Mammalian Telomerase-Associated Protein
摘要：
The telomerase ribonucleoprotein catalyzes the addition of new telomeres onto chromosome ends. A gene encoding a mammalian telomerase homolog called TP1 (telomerase-associated protein 1) was identified and cloned. TP1 exhibited extensive amino acid similarity to the Tetrahymena telomerase protein p80 and was shown to interact specifically with mammalian telomerase RNA. Antiserum to TP1 immunoprecipitated telomerase activity from cell extracts, suggesting that TP1 is associated with telomerase in vivo. The identification of TP1 suggests that telomerase-associated proteins are conserved from ciliates to humans.
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关键词：
Animals Humans Mice Cell Line Tumor Cells, Cultured RNA Telomerase Blotting, Northern Cloning, Molecular Transfection
DOI：
10.1126/science.275.5302.973
被引量：
年份：
1997
Wiley
Semantic Scholar
万方医学
NCBI
Oxford Univ Press
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