Development of tetrahydrofuran chiral synthons by enzymatic approach: Improved synthesis of a strong agonist of platelet activating factor
摘要：
Bicyclic meso diester 7 was found to undergo enantioselective hydrolysis with PLE (pig liver esterase) generating the chiral monoester 8 in excellent yield which high enantiomeric excess. The chiral monoester 8 was successfully utilized in the improved synthesis of 1R-cis-THF derivative (1), a strong agonist of PAF which we previously developed.
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关键词：
pig liver esterase enantioselective hydrolysis tetrahydrofuran chiral synthon platelet activating factor
DOI：
10.1016/S0040-4039(00)91866-5
被引量：
年份：
1992
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