Complete Regioselection in Palladium-Catalyzed Arylation and Alkenylation of Allylic Alcohols with Hypervalent Iodonium Salts.
摘要：
Total synthesis of the extraordinary antineoplastic constituent, dolastatin 10, from the Indian Ocean mollusc Dolabella auricularia has been summarized. The final synthetic step involved diethyl cyanophosphonate-mediated coupling of Dov-Val-Dil with Dap-Doe. Improved syntheses of these important precursors has led to a very practical synthesis of natural dolastatin 10. Important details of the HPLC and high-field (500 MHz) NMR characterization techniques employed to confirm the purity of dolastatin 10 have been recorded.
展开
DOI：
10.1021/jo951923t
被引量：
年份：
1996
通过文献互助平台发起求助，成功后即可免费获取论文全文。
请先登入
相似文献
参考文献
引证文献
引用走势
2006
被引量：42
辅助模式
0
引用
文献可以批量引用啦~
欢迎点我试用！
