Another way to die: autophagic programmed cell death

Programmed cell death (PCD) is one of the important terminal paths for the cells of metazoans, and is involved in a variety of biological events that inclu...

Y Tsujimoto，S Shimizu - 《Cell Death & Differentiation》

WNT-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor–Mediated Transcription

Wnt signaling plays a critical role in development and oncogenesis. Although significant progress has been made in understanding the downstream signaling c...

S Chen，DC Guttridge，Z You，... - 《Journal of Cell Biology》

Pathogenesis of myeloma bone disease

Myeloma bone disease is characterized by osteolytic bone destruction that is not followed by reactive new bone formation. This results in a purely lytic pr...

GD Roodman - 《Blood Cells Molecules & Diseases》

...-catenin signaling and cancer.

Focuses on the relationship between beta-catenin and cancer. Regulation of beta-catenin levels and transcription; Importance of beta-catenin signaling to t...

Morin，Patrice，J. - 《Bioessays》

Pathogenesis of myeloma bone disease

Multiple myeloma (MM) is the most common cancer to involve bone with up to 90% of patients developing bone lesions. The bone lesions are purely osteolytic ...

GD Roodman - 《Journal of Cellular Biochemistry》

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

Decreased activity of osteoblasts (OBs) contributes to osteolytic lesions in multiple myeloma (MM). The production of the soluble Wnt inhibitor Dickkopf-1 ...

M Fulciniti，S Vallet，S Ettenberg，... - 《Blood》

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

The unrestrained growth of tumor cells is generally attributed to mutations in essential growth control genes, but tumor cells are also influenced by signa...

Derksen PWB，E Tjin，HP Meijer，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Targeting the β-catenin/TCF transcriptional complex in the treatment of multiple myeloma

Multiple myeloma (MM) is an invariably fatal form of cancer characterized by clonal proliferation of malignant plasma cells in the bone marrow. The canonic...

K Sukhdeo，M Mani，Y Zhang，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.

Autophagy has long been viewed as a process to remove long-lived or misfolded protein aggregates and aging and damaged organelles. Our study identified a p...

G Chan，W Cao，B Lan，... - 《Nature Cell Biology》

Activation of Wnt/beta-catenin protein signaling induces mitochondria-mediated apoptosis in hematopoietic progenitor cells

Autophagy has long been viewed as a process to remove long-lived or misfolded protein aggregates and aging and damaged organelles. Our study identified a p...

M Ming，S Wang，W Wu，...