Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
摘要：
We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway. Smac promotes caspase-9 activation by binding to i nhibitor of a poptosis p roteins, IAPs, and removing their inhibitory activity. Smac is normally a mitochondrial protein but is released into the cytosol when cells undergo apoptosis. Mitochondrial import and cleavage of its signal peptide are required for Smac to gain its apoptotic activity. Overexpression of Smac increases cells' sensitivity to apoptotic stimuli. Smac is the second mitochondrial protein, along with cytochrome c, that promotes apoptosis by activating caspases.
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关键词：
Hela Cells Mitochondria Cytosol Humans Cytochrome c Group Enzyme Precursors Caspases Intracellular Signaling Peptides and Proteins Protein Sorting Signals Proteins
DOI：
10.1016/S0092-8674(00)00008-8
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年份：
2000
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