NF-κB is a target of AKT in anti-apoptotic PDGF signalling

来自 EBSCO

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143

作者：

JA Romashkova，SS Makarov

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摘要：

The mechanisms of cell proliferation and transformation are intrinsically linked to the process of apoptosis: the default of proliferating cells is to die unless specific survival signals are provided. Platelet-derived growth factor (PDGF) is a principal survival factor that inhibits apoptosis and promotes proliferation, but the mechanisms mediating its anti-apoptotic properties are not completely understood. Here we show that the transcription factor NF-κBis important in PDGF signalling. NF-κB transmits two signals: one is required for the induction of proto-oncogeneand proliferation, and the second, an anti-apoptotic signal, counterbalances c-Myc cytotoxicity. We have traced a putative pathway whereby PDGF activates NF-κB through Ras and phospatidylinositol-3-kinase (PI(3)K) to the PKB/Akt protein kinase and the IκB kinase (IKK); NF-κB thus appears to be a target of the anti-apoptotic Ras/PI(3)K/Akt pathway. We show that, upon PDGF stimulation, Akt transiently associateswith IKK and induces IKK activation. These findings establish a role for NF-κB in growth factor signalling anddefine an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κB pathway, thus linking anti-apoptotic signalling with transcription machinery.

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关键词：

mechanics of nonwovens direction distribution function orient at ion distribution function elastic properties/constants fibre network theory nonwovens' modelling

DOI：

10.1038/43474

被引量：

4711