Catalytic enantioselective fluorination of oxindoles
摘要：
We have developed a highly efficient catalytic enantioselective fluorination of oxindole derivatives. In the presence of a catalytic amount of chiral Pd complex 2 (2.5 mol %), various substrates, including aryl- and alkyl-substituted oxindoles, were fluorinated in a highly enantioselective manner (up to 96% ee). In addition, when R was a hydrogen atom, enantioselective fluorination followed by solvolysis gave a monofluorinated ester with up to 93% ee. To our knowledge, this is the first example of catalytic enantioselective fluorination of oxindoles.
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关键词：
indole derivatives, isoindole derivatives halogenation catalysis, phase‐transfer catalysis diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
DOI：
10.1055/s-2005-916016
被引量：
年份：
2005
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