PI3K signalling: the path to discovery and understanding.
摘要：
Over the past two decades, our understanding of phospoinositide 3-kinases (PI3Ks) has progressed from the identification of an enzymatic activity associated with growth factors, GPCRs and certain oncogene products to a disease target in cancer and inflammation, with PI3K inhibitors currently in clinical trials. Elucidation of PI3K-dependent networks led to the discovery of the phosphoinositide-binding PH, PX and FYVE domains as conduits of intracellular lipid signalling, the determination of the molecular function of the tumour suppressor PTEN and the identification of AKT and mTOR protein kinases as key regulators of cell growth. Here we look back at the main discoveries that shaped the PI3K field.
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关键词：
Animals Humans Antineoplastic Agents Enzyme Inhibitors Signal Transduction Protein Structure, Tertiary Phosphorylation Clinical Trials as Topic Neoplasms Phosphatidylinositol 3-Kinases
DOI：
10.1038/nrm3290
被引量：
年份：
2012
Taylor & Francis
Nature
Springer
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