SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes
摘要：
In the present study, we have examined whether IKKβ [IκB (inhibitor of nuclear factor κB) kinase β] plays a role in feedback inhibition of the insulin signalling cascade. Insulin induces the phosphorylation of IKKβ, in vitro and in vivo, and this effect is dependent on intact signalling via PI3K (phosphoinositide 3-kinase), but not PKB (protein kinase B). To test the hypothesis that insulin...
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关键词：
Animals Mice 3T3-L1 Cells Inflammation Insulin Resistance Sirtuins Insulin Glucose Signal Transduction RNA Interference
DOI：
10.1128/MCB.00705-08
被引量：
年份：
2009
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