Identification of a naturally occurring transforming variant of the p65 subunit of NF-kappa B.
摘要：
Transcription factor NF-κB comprises two proteins, p50 and p65, that have sequence similarity to the v-rel oncogene. In primary hematopoietic cell populations an alternatively spliced form of NF-κ B p65 mRNA was observed that encoded a protein designated p65Δ. Expression of the p65Δ cDNA in Rat-1 fibroblasts resulted in focus formation, anchorage-independent growth in soft agar, and tumor formation in athymic nude mice, effects not obtained with expression of p65 or a p65Δ mutant that contains a disruption within the transcriptional activation domain. Thus, p65Δ, which associated weakly and interfered with DNA binding by p65, may sequester an essential limiting regulatory factor or factors required for NF-κ B function.
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DOI：
10.1126/science.256.5055.367
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年份：
1992
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