Pharmaceutical inhibition of glycogen synthetase kinase-3 reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model
摘要：
One of the major clinical features of multiple myeloma is the development of a unique osteolytic bone disease, characterized by progressive and devastating bone destruction, bone pain, pathological fractures and hypercalcemia. As our understanding of the molecular mechanisms involved in the development of myeloma bone disease increases, new approaches have been identified for the treatment of...
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关键词：
Animals Mice, Inbred C57BL Humans Mice Bone Diseases Disease Models, Animal Oximes Indoles Alkaline Phosphatase Glycogen Synthase Kinase 3
DOI：
10.1182/blood-2010-09-308171
被引量：
年份：
2011
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