Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis
摘要：
Normal immature thymocytes respond to activation by undergoing programmed cell death (apoptosis), a physiological deletion mechanism involved in the selection of the T-cell repertoire. In this article, Jean Claude Ameisen and André Capron suggest that inappropriate induction o f a form o f programmed T-cell death could account for both qualitative and quantitative helper T-cell defects of HIV-infected patients. A model of AIDS pathogenesis is presented that may explain several features of HIV infection, including evolution of the disease and the development o f defects in nom mmunological organs.
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关键词：
CD4-Positive T-Lymphocytes Hematopoietic Stem Cells AIDS Dementia Complex Endodeoxyribonucleases HIV Envelope Protein gp120 Mitogens Signal Transduction Lymphocyte Activation Cell Survival Gene Expression Regulation
DOI：
10.1016/0167-5699(91)90092-8
被引量：
年份：
1991
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