Pharmacokinetics and metabolism in early drug discovery
摘要：
The need for high-throughput approaches in absorption, distribution, metabolism and excretion studies is driven by the impact of high-speed chemistry and pharmacological screening. Perhaps an even greater impact is that these studies will, in the future, provide large data sets that can be used to predict biological events related to absorption, bioavailability and metabolism of drugs. Through linking of in silico and in vitro methods, considerable progress has recently been made towards this future perspective. Despite this progress, these approaches do not yet replace in vivo methods.
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关键词：
ADME absorption, distribution, metabolism, excretion CYP3A4 cytochrome P450 3A4 HTS high-throughput screening IAM immobilised artificial membrane P-gp P-glycoprotein
DOI：
10.1016/S1367-5931(99)80056-8
被引量：
年份：
1999
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