Selected glimpses into the activation and function of Src kinase.
摘要：
Since the discovery of the and genes and their products, much progress has been made in the elucidation of the structure, regulation, , and function of the protein. is a non-receptor protein tyrosine kinase that transduces signals that are involved in the control of a variety of cellular processes such as proliferation, differentiation, motility, and . is normally maintained in an inactive state, but can be activated transiently during cellular events such as , or constitutively by abnormal events such as mutation (i.e. and some ). Activation of occurs as a result of disruption of the negative regulatory processes that normally suppress activity, and understanding the various mechanisms behind activation has been a target of intense study. associates with cellular , in particular the , and endosomal . Studies indicate that the different subcellular of could be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and/or trafficking. This review will discuss the history behind the discovery and initial characterization of and the regulatory mechanisms of activation, in particular, regulation by modification of the carboxy-terminal regulatory tyrosine by and kinases. Its focus will then turn to the different subcellular of and the possible roles of nuclear and perinuclear targets of . Finally, a brief section will review some of our present knowledge regarding involvement in .
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DOI：
10.1049/el:20030313
被引量：
年份：
2000
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