摘要：

Palladium(0)-catalyzed cyclization of propargyl chlorides and carbonates bearing hydroxy and benzamide groups as internal nucleophiles stereoselectively provides functionalized tetrahydrofuran. Cyclization reactivity is dependent on the relative configuration of the benzamide and leaving groups, and on the nature of the leaving groups. This bis-cyclization was used as the key step in a short-step total synthesis of pachastrissamine.

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