Nonresolving Inflammation

Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an inherent risk because inflammation can damage tissue and necrosi...

Carl，Nathan，and，... - 《Cell》

Overview of cell death signaling pathways

Apoptosis plays an important role in development and maintenance of tissue homeostasis. Intensive efforts have been made to explore the molecular mechanism...

Zhaoyu，Jin，&，... - 《Cancer Biology & Therapy》

Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

Apoptotic cells expose phosphatidylserine and are swiftly engulfed by macrophages. Milk fat globule epidermal growth factor (EGF) factor 8 (MFG-E8) is a pr...

R Hanayama，M Tanaka，K Miyasaka，... - 《Science》

Immunogenic and tolerogenic cell death.

The immune system is routinely exposed to dead cells during normal cell turnover, injury and infection. Mechanisms must exist to discriminate between diffe...

DR Green，T Ferguson，L Zitvogel，... - 《Nature Reviews Immunology》

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

In the 1980s, exosomes were described as vesicles

Colombo，Marina，Thery，... - 《Annual Review of Cell & Developmental Biology》

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles.

In the 1980s, exosomes were described as vesicles of endosomal origin secreted from reticulocytes. Interest increased around these extracellular vesicles, ...

Colombo，Marina，Raposo，... - 《Annual Review of Cell & Developmental Biology》

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis The Importance of Lesion Stage and Phagocytic Efficiency

Macrophage apoptosis occurs throughout all stages of atherosclerosis, yet new findings in vivo suggest that the consequences of this event may be very diff...

Tabas，I. - 《Arterioscler Thromb Vasc Biol》

Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression.

Hepatocyte apoptosis by death receptors, hepatic inflammation, and fibrosis are prominent features of liver diseases. However, the link between these proce...

A Canbay，AE Feldstein，H Higuchi，... - 《Hepatology》

Annexin I is an endogenous ligand that mediates apoptotic cell engulfment.

Engulfment of apoptotic cells requires presentation of new cell surface ligands by the dying cells. Using a differential proteomics technology, we identify...

S Arur，UE Uche，K Rezaul，... - 《Developmental Cell》

Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency.

Macrophage apoptosis occurs throughout all stages of atherosclerosis, yet new findings in vivo suggest that the consequences of this event may be very diff...

Ira，Tabas - 《Arteriosclerosis Thrombosis & Vascular Biology》