Clonal selection and learning in the antibody system
摘要：
Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of ordered gene rearrangements which must be successfully performed if the cell is to survive. A second selection process occurs during immune responses in which a new antibody repertoire is generated through somatic hypermutation. Here only mutants binding antigen with high affinity survive to become memory cells. Cells expressing autoreactive receptors are counter-selected at both stages. This stringent positive and negative selection allows the generation and diversification of cells while rigorously controlling their specificity.
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关键词：
Pre-b-cells Chain gene rearrangement Reactive lymphocytes-b Immunoglobulin heavy-chains D-mu protein Immune-response Germinal-centers Bone-marrow Somatic hypermutation Transgenic mice
DOI：
10.1038/381751a0
被引量：
年份：
1996
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