Biosynthetically lipid-modified human scFv fragments from phage display libraries as targeting molecules for immunoliposomes
摘要：
A anti-single chain (sc) Fv antibody fragment from a synthetic phage antibody display library was biosynthetically -tagged by using sequences. The purified anti-scFv was incorporated into liposomes by detergent dilution. Anti-immunoliposomes were shown to bind specifically in a dose- and time-dependent manner to + cell lines and + B-lymphocytes present in freshly isolated samples of blood mononuclear cells. The immunoliposomes were demonstrated to accumulate in compartments. Biosynthetically -tagged scFv antibody fragments isolated from phage display libraries may facilitate the construction of immunoliposomes with improved properties.
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DOI：
10.1016/S0014-5793(96)01335-X
被引量：
年份：
1996
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