Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor
摘要：
The alpha5 subunit of the GABA(A) receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of alpha5-containing GABA(A) receptors has been explored by targeted disruption of the alpha5 gene in mice. The alpha5 -/- mice showed a significantly improved performance in a water maze model of spatial learning, whereas the performance in non-hippocampal-dependent learning and in anxiety tasks were unaltered in comparison with wild-type controls. In the CA1 region of hippocampal brain slices from alpha5 -/- mice, the amplitude of the IPSCs was decreased, and paired-pulse facilitation of field EPSP (fEPSP) amplitudes was enhanced. These data suggest that alpha5-containing GABA(A) receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the CA1 region of the hippocampus.
展开
关键词：
Hippocampus Animals Mice, Knockout Mice gamma-Aminobutyric Acid Receptors, GABA-A Protein Subunits Behavior, Animal Learning Avoidance Learning
DOI：
20026436
被引量：
年份：
2002
国家科技图书文献中心
(权威机构)
Semantic Scholar
(全网免费下载)
掌桥科研
万方医学
Ingenta
查看更多
NCBI
NCBI
Oxford Univ Press
Europe PMC
JBC
ResearchGate
ResearchGate
(全网免费下载)
jneurosci.org
(全网免费下载)
jneurosci.org
cghjournal.org
mendeley.com
www.socolar.com
molpharm.aspetjournals.org
pubget.com
emboj.embopress.org
discovery.ucl.ac.uk
fasebj.org
jn.physiology.org
SAGE
learnmem.cshlp.org
deepdyve.com
mysciencework.com
jacionline.org
cronfa.swan.ac.uk
pubfacts.com
学术范
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
