摘要：

Three new prenylated catechol dimers have been isolated from the tropical shrub Pothomorphe peltata (Piperaceae). The structures of peltatol A (1), peltatol B (2), and peltatol C (3) were determined by extensive spectroscopic analyses. Peltatols A-C inhibited HIV-1 induced cell killing at subcytotoxic concentrations of 1-10-mu-g/mL. The monomeric catechol derivative 4-nerolidyleatechol (4) was active in a phorbol receptor binding assay (IC50 = 35-mu-g/mL) but inactive against HIV. The diphenyl ethers, peltatols B (2) and C (3), were interconvertible in solution (MeOH, DMSO) at room temperature.

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