Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.
摘要：
Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. Approximately half of IMTs carry rearrangements of the anaplastic lymphoma kinase (ALK) locus on chromosome 2p23, causing aberrant ALK expression. We report a sustained partial response to the ALK inhibitor crizotinib (PF-02341066, Pfizer) in a patient with ALK-translocated IMT, as compared with no observed activity in another patient without the ALK translocation. These results support the dependence of ALK-rearranged tumors on ALK-mediated signaling and suggest a therapeutic strategy for genomically identified patients with the aggressive form of this soft-tissue tumor. (Funded by Pfizer and others; ClinicalTrials.gov number, NCT00585195.).
展开
关键词：
Humans Neoplasms, Muscle Tissue Abdominal Neoplasms Granuloma, Plasma Cell Pyrazoles Pyridines Receptors, Growth Factor Protein Kinase Inhibitors Mutation Protein-Tyrosine Kinases
DOI：
10.1056/NEJMoa1007056
被引量：
年份：
2010
BMJ
国家科技图书文献中心
(权威机构)
掌桥科研
万方医学
dx.doi.org
查看更多
NCBI
NCBI
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
AACR
ResearchGate
ResearchGate
(全网免费下载)
ProQuest
repository.cshl.edu
dmm.biologists.org
pubs.rsna.org
cghjournal.org
nejm.org
(全网免费下载)
scienceopen.com
molecularcasestudies.cshlp.org
mysciencework.com
science-open.com
pubfacts.com
biochemj.org
pubget.com
jacionline.org
jco.ascopubs.org
mendeley.com
www.socolar.com
学术范
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
