Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-pegda hybrid hydrogels
摘要:
Synthetic hydrogels are important biomaterials for many biomedical applications and hydrogels produced via photo gelation have shown particular promise. In this paper, we describe a new family of biodegradable hybrid hydrogels fabricated in an aqueous solution via a long wavelength UV- photocrosslinking using maleic chitosan and polyethylene glycol diacrylate (PEGDA) as precursors. The maleic chitosan precursor was prepared by a simple one-step chemical modification of chitosan with high yields, and characterized by FTIR, 1H NMR and 13C NMR. Maleic chitosan and PEGDA precursors at a wide range of weight feed ratios were mixed in an aqueous solution and directly photo-crosslinked...
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2010
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