Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
摘要：
The presence and function of CB2receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2receptor messenger RNA and protein localization on brainstem neurons. These functional CB2receptors in the brainstem were activated by a CB2receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1receptors. CB2receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.
展开
关键词：
Animals Ferrets Mice Rats Brain Stem Cerebellum Cerebral Cortex Arachidonic Acids Receptor, Cannabinoid, CB2 Reverse Transcriptase Polymerase Chain Reaction
DOI：
10.1126/science.1115740
被引量：
年份：
2005
Taylor & Francis
Wiley
BMJ
掌桥科研
万方医学
查看更多
doi.org
Oxford Univ Press
APA
JSTOR
NCBI
Europe PMC
JBC
dialnet.unirioja.es
adsabs.harvard.edu
AGRIS
ResearchGate
(全网免费下载)
ResearchGate
ProQuest
EBSCO
fasebj.org
ajpheart.physiology.org
mysciencework.com
science.sciencemag.org
(全网免费下载)
escholarship.org
jpet.aspetjournals.org
biochemj.org
escholarship.org
(全网免费下载)
jimmunol.org
eje-online.org
perspectivesinmedicine.cshlp.org
sciencemag.org
(全网免费下载)
pubfacts.com
jleukbio.org
haematologica.org
cghjournal.org
jlr.org
hyper.ahajournals.org
jacionline.org
biologicalpsychiatryjournal.com
www.socolar.com
leaddiscovery.co.uk
psycontent.com
sciencemag.org
学术范
学术范
(全网免费下载)
scienceopen.com
deepdyve.com
science-open.com
ResearchGate
(全网免费下载)
sciencemag.org
(全网免费下载)
science.sciencemag.org
(全网免费下载)
学术范
(全网免费下载)
escholarship.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
