Essential Metalloelement Chelates Facilitate Repair of RadiationInjury

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作者：

JRJ Sorenson，LSF Soderberg，LW Chang，RB Walker

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摘要：

Treatment with essential metalloelement (Cu, Fe, Mn, and Zn) chelates or combinations of thembeforeand/orafterradiation injury is a useful approach to overcoming radiation injury. No other agents are known to increase survival when they are used to treatafterirradiation, in a radiorecovery treatment paradigm. These chelates may be useful in facilitatingde novosyntheses of essential metalloelement-dependent enzymes required to repair radiation injury. Reports of radioprotection, which involves treatmentbeforeirradiation, with calcium-channel blockers, acyl Melatonin homologs, and substituted anilines, which may serve as chelating agents after biochemical modificationin vivo, as well as Curcumin, which is a chelating agent, have been included in this review. These inclusions are intended to suggest additional approaches to combination treatments that may be useful in facilitating radiation recovery. These approaches to radioprotection and radiorecovery offer promise in facilitating recovery from radiation-induced injury experienced by patients undergoing radiotherapy for neoplastic disease and by individuals who experience environmental, occupational, or accidental exposure to ultraviolet, x-ray, or γ-ray radiation. Since there are no existing treatments of radiation-injury intended to facilitate tissue repair, studies of essential metalloelement chelates and combinations of them, as well as combinations of them with existing organic radioprotectants, seem worthwhile.

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DOI：

10.1155/MBD.2001.215

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年份：

2001