Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo.
摘要：
Our previous study reported that an osteopontin-derived SVVYGLR activates the , migration and tube formation abilities of endothelial cells in vitro. The present study investigated due to synthetic SVVYGLR and mutant in vivo. Mutant (n = 7) were synthesized by substituting alanine (A) for one of the 7 amino acids comprising SVVYGLR. In dorsal air sac assay, dorsal skin 5 days after implantation of a chamber filled with SVVYGLR had approximately the same number of newly formed blood vessels to that filled with vascular endothelial growth factor (). The ability of due to SVVAGLR was significantly lower than that due to other 6 mutant and SVVYGLR. This indicates that tyrosine (Y) plays an important role in due to SVVYGLR.
展开
DOI：
10.4012/dmj.23.650
被引量：
年份：
2004
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
