The let-7 family of microRNAs

来自 dx.doi.org

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阅读量：

265

作者：

S Roush，FJ Slack

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摘要：

The first two known microRNAs (miRNAs), lin-4 and let-7, were originally discovered in the nematode Caenorhabditis elegans and control the timing of stem-cell division and differentiation. let-7 was subsequently found as the first known human miRNA. let-7 and its family members are highly conserved across species in sequence and function, and misregulation of let-7 leads to a less differentiated cellular state and the development of cell-based diseases such as cancer. Although much research has been devoted to let-7 target prediction and to understanding its biological role, research into what regulates let-7 has only just begun. Here, we review let-7-family conservation and the recent advances in understanding how let-7-expression is regulated at the transcriptional and post-transcriptional levels across species. A greater understanding of what controls let-7 expression might enable the development of treatments to fight or prevent many cancers.

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关键词：

Animals Humans Caenorhabditis elegans MicroRNAs Base Sequence Gene Expression Regulation Molecular Sequence Data

DOI：

10.1016/j.tcb.2008.07.007

被引量：

1929

年份：

2008